Find patient medical information for nicardipine oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Nicardipine should be administered by continuous intravenous infusion only. Nicardipine 10mg10ml solution for injection summary of product. Fully updated coverage includes the newest iv treatments with magnesium, conivaptan, potassium, and nicardipine, helping you provide the most effective care possible.
Critical care intravenous drug administration guide. Fda package insert for nicardipine contains no information regarding iv compatibility. Nicardipine yc93 is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic. Though vastly different, these tools share a basic truth. Premixed injection for intravenous administration contains 20 mg of nicardipine hydrochloride per 200 ml 0. Intravenous nicardipine quick reference cardene pdf. Iv nicardipine was shown to be compatible and the shortterm. If oral nicardipine is to be used after iv nicardipine, administer the first dose 1 hour prior to discontinuation of the iv infusion. Initiate therapy at 5 mghour as a continuous iv infusion.
Nicardipine hydrochloride monograph for professionals. Nicardipine hydrochloride injection produces significant decreases in systemic vascular resistance. It is available in by mouth and intravenous formulations. Three overdosages with nicardipine or nicardipine have been reported. Nicardipine is a calcium channel blocker that relaxes widens your blood vessels, which makes it easier for the heart to pump and reduces its workload nicardipine is used to treat hypertension high blood pressure and angina nicardipine may also be used for purposes not listed in this medication guide. Assess heart rate, ecg, and heart sounds, especially during exercise see appendices g, h. Cardene iv nicardipine hydrochloride injection label fda. Key words heparin sodium, nicardipine, compatibility, injection via. Nicardipine 10mg10ml solution for injection summary of.
Nicardipine relaxes widens your blood vessels, which makes it easier for the heart to pump and reduces its workload. Annex i list of the names, pharmaceutical form, strengths. Nicardipine drug monograph pediatric care online aap. Transition from iv nicardipine to an oral antihypertensive agent. Drug monographs include detailed information on dosing for specific indications, adverse effects, comparative efficacy and pharmacokinetics. Information in this booklet should be used as a guide only.
Management of chronic stable angina pectoris alone or in combination with other antianginal agents. The compatibility of nicardipine hydrochloride injection with various icu medications during simulated ysite injection. Nicardipine is a second generation slow calcium channel inhibitor, and belongs to the phenyldihydropyridine group. Irregular heart beat, shortness of breath, swelling of the feet, pronounced dizziness, nausea, or drop in bp. It belongs to the dihydropyridine class of calcium channel blockers.
Nicardipine 10 mg10 ml solution for injection is indicated for the treatment of acute lifethreatening. Compatibility of heparin sodium in intravenous line with. Current drug dosing charts for 48 of the most common, and most difficult to administer, intravenous infusion critical care drugs ensure that the information you need is readily. Includes drug interactions drugdrug, druglab test, drugfood, drugpregnancy, druglactation and drugalcohol interactions, trissels iv compatibility for single drugs or drug combinations. Trissel, this tool provides clinicians with access to the information they need to answer tough compatibility questions within the workflow. Dailymed cardene iv nicardipine hydrochloride injection. To determine the physical compatibility of propofol injection with 77 other drug products using two methods not previously reported.
Medscape indicationspecific dosing for cardene, cardene iv nicardipine. Pocket reference for icu staff critical care medicine services 2000 2nd edition tripler army medical center. Nicardipine is prescribed for the treatment of high blood pressure and angina heart pain. Nicardipine injection is compatible with the following iv solutions. The initial infusion rate of 5mghr iv may be increased by 2.
Cardene nicardipine hydrochloride is a calcium ion influx inhibitor slow channel blocker or calcium channel blocker. If an oral antihypertensive agent other than nicardipine is to be used after iv nicardipine, initiate therapy upon discontinuation of iv nicardipine. Two occurred in adults, 1 of whom ingested 600 mg of nicardipine and the other 2160 mg of nicardipine. Nicardipine demonstrates strong coronary and cerebral vasodilatory activity. Trissel, fashp, 2010, american society of healthsystem pharmacists. Nicardipine is a second generation calcium channel blocker used in the treatment of hypertension and stable angina pectoris. Iv geriatric patients, debilitated patients, or asa iii iv patients. Studies in patients who received intravenous nicardipine. Nicardipine side effects, dosage, interactions drugs. Nicardipine cardene, cardene sr belongs to a class of drugs referred to as calcium channel blockers ccbs. Nicardipine cardene is a medication used to treat high blood pressure and angina.
Propofol compatibility with other intravenous drug. For prolonged control of blood pressure, transfer patients to oral medication as soon as their clinical condition permits. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities. The compatibility of nicardipine hydrochloride injection. Medications information ciap clinical information access. Premixed injection is available as a readytouse sterile, nonpyrogenic, clear, colorless to yellow, isoosmotic solution for intravenous administration in a 200 ml galaxy container with 20 mg 0. Nicardipine has a greater selectivity for ltype calcium channels in vascular smooth muscle than cardiac myocytes.
Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest pain, shortness of breath, fainting, and fatigueweakness. Incompatibilities are based on meeting any of the following criteria. Premixed injection is a calcium channel blocker indicated for the shortterm treatment of hypertension when oral therapy is not feasible. Cardene, cardene iv nicardipine dosing, indications, interactions. In a study of intraarterially administered nicardipine hydrochloride injection, the degree of vasodilation and the resultant decrease in blood pressure were more prominent in hypertensive patients than in normotensive volunteers.
Intravenous compatibility chart free html5 flip book. Intravenous nicardipine or invented name is indicated for the treatment of acute lifethreatening hypertension, particularly in the. It takes spikes, syringes, and pumps to make an intravenous iv solution. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. Quick search includes some brandtrade names enter search term below then hit search. If transitioning to po nicardipine, initiate po dosing 1 hr before discontinuance of iv. Patients are always placed on telemetry and noninvasive bp. In a case report of a 68kg girl, aged 14 years, with glomerulonephritis who was initially maintained on a nicardipine infusion dosing range. Each of 77 drug products were mixed with 1 an equal volume of propofol injection, 2 an equal volume of propofol injection with methylene blue added, and 3 an equal volume of the separated aqueous phase of propofol injection. Cardene iv nicardipine hydrochloride premixed injection, for intravenous use initial u. Summary of product characteristics and package leaflet. Cardene iv nicardipine hydrochloride premixed injection for intravenous use.
Trissels iv chek api is an electronic tool that verifies the compatibility and stability of parenteral medications. List item nicardipine article31 referral annex iii. Propofol compatibility with other intravenous drug products. A pharmacy workflow management system and automated compounding system can help streamline pharmacy operations. Nicardipene therapy has been associated with a low rate of transient serum enzyme elevations, but has not been linked convincingly to. Cardene, cardene iv nicardipine dosing, indications. Cardene, cardene sr nicardipine uses, side effects. Iv, rapid reduction of bp in the management of acute severe hypertension and lifethreatening symptoms in children and adolescents. Cardene iv nicardipine hydrochloride premixed injection in 0. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. A patient must have a central line available to receive these. There is no data regarding the conversion of nicardipine iv infusion to oral dosing in pediatric patients. Intravenous administration of formulary medications. Current drug dosing charts for 48 of the most common, and most difficult to administer, intravenous infusion critical care drugs ensure that the information you need is readily available.389 763 574 963 1444 1115 25 1517 448 1395 1040 281 924 850 1478 96 153 571 267 348 481 401 715 351 1284 195 439 1218 1035 206 820 851 1420 782 1197